hrp0086p2-p870 | Syndromes: Mechanisms and Management P2 | ESPE2016

Children with Down’s Syndrome Show Quantitative, Phenotypical and Functional Differences of Effector T-Cells Compared to Immunocompetent Controls

Schoch Justine , Schmidt Tina , Jung Anna-Maria , Kastner Michael , Abdul-Khaliq Hashim , Gortner Ludwig , Sester Martina , Rohrer Tilman

Background: Trisomy 21 is associated with an increased susceptibility to respiratory infections.Objective and hypotheses: For a more detailed characterization of the adaptive immune response, we analyzed the cellular and humoral immunity to specific pathogens in blood samples of 40 children with DownÂ’s syndrome in comparison to 51 age-matched controls.Method: We quantitatively analyzed lymphocyte subpopulations using flow cyto...